CHIMERA: “The Chinese Vampire Virus” – Covid19 HIV-1 Inserts Found To Be Unnatural

SARS_virion

CHIMERA

“The Chinese Vampire Virus”

Chinese Covid19 HIV-1 Inserts

Found To Be Unnatural

Edited by Robrt D. Morningstar

Indian microbiologigists Expose 4 Unnatural HIV-1 Inserts

s found in Chinese Covid19 samples

Quote:

“The finding of 4 unique inserts in the 2019-nCoV, all of which have identity /similarity to amino acid residues in key structural proteins of HIV-1 is unlikely to be fortuitous in nature.”

Editor’s Note – Emphasis mine

This article has been edited by Robert D. Morningstar and is derived from an article and other information archived at

bioRxivhttps://www.biorxiv.org/content/10.1101/2020.01.30.927871v1.full

Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag

By
Prashant PradhanAshutosh Kumar PandeyAkhilesh MishraParul GuptaPraveen Kumar TripathiManojBalakrishnan MenonJames GomesPerumal VivekanandanBishwajit Kundu

biorxiv.org/content/10.110

*******

Abstract

We are currently witnessing a major epidemic caused by the 2019 novel coronavirus (2019-nCoV). The evolution of 2019-nCoV remains elusive. We found 4 insertions in the spike glycoprotein (S) which are unique to the 2019-nCoV and are not present in other coronaviruses. Importantly, amino acid residues in all the 4 inserts have identity or similarity to those in the HIV-1 gp120 or HIV-1 Gag.

Interestingly, despite the inserts being discontinuous on the primary amino acid sequence, 3D-modelling of the 2019-nCoV suggests that they converge to constitute the receptor binding site.

The finding of 4 unique inserts in the 2019-nCoV, all of which have identity or similarity to amino acid residues in key structural proteins of HIV-1 is unlikely to be fortuitous in nature.

This work provides yet unknown insights on 2019-nCoV and sheds light on the evolution and pathogenicity of this virus with important implications for diagnosis of this virus.

 

Read the FULL Report here:

 Uncanny similarity of unique inserts in the 2019-nCoV spike protein

to HIV-1 gp120 and Gag

The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. 

Conclusions

Our analysis of the spike glycoprotein of 2019-nCoV revealed several interesting findings:

First, we identified 4 unique inserts in the 2019-nCoV spike glycoprotein that are not present in any other coronavirus reported till date.

To our surprise, all the 4 inserts in the 2019-nCoV mapped to short segments of amino acids in the HIV-1 gp120 and Gag among all annotated virus proteins in the NCBI database. This uncanny similarity of novel inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag is unlikely to be fortuitous.

Further, 3D modelling suggests that atleast 3 of the unique inserts which are non-contiguous in the primary protein sequence of the 2019-nCoV spike glycoprotein converge to constitute the key components of the receptor binding site.

Of note, all the 4 inserts have pI values of around 10 that may facilitate virus-host interactions. Taken together, our findings suggest unconventional evolution of 2019-nCoV that warrants further investigation. Our work highlights novel evolutionary aspects of the 2019-nCoV and has implications on the pathogenesis and diagnosis of this virus.

*******

Editors Update:

Uncanny similarity of unique inserts in the 2019-nCoV spike protein

to HIV-1 gp120 and  Gag

Prashant PradhanAshutosh Kumar Pandey
Akhilesh MishraParul GuptaPraveen Kumar TripathiManojBalakrishnan MenonJames Gomes
Perumal VivekanandanBishwajit Kundu

Kusuma School of biological sciences,

Indian institute of technology,

New Delhi-110016, India.

2 Acharya Narendra Dev College, University of Delhi, New Delhi-110019, India

This paper has been withdrawn by its authors. They intend to revise it in response to comments received from the research community on their technical approach and their interp
bioRxiv is receiving many new papers on coronavirus 2019-nCoV.   A reminder: these are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information.
*******

Edited by Robert D. Morningstar

 

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